Publications | LeitchLab

The Power of High Throughput Experimentation: General Topics and Enabling Technologies for Synthesis and Catalysis 2022, 1, 35-57. ACS Symposium Series.

48.

Jingru Lu, Irina Paci,* and David C. Leitch*

A broadly applicable quantitative relative reactivity model for nucleophilic aromatic substitution (SNAr) using simple descriptors

Chem. Sci. 2022, 13, 12681-12695.

ChemRxiv 2022, DOI: 10.26434/chemrxiv-2022-71bzc.

47.

François Richard, Sidonie Aubert, Tania Katsina, Luuk Reinalda, David Palomas, Rachel Crespo-Otero, Jingjun Huang, David C. Leitch, Carlos Mateos, and Stellios Arseniyadis*

Enantioselective synthesis of γ-butenolides through Pd-catalysed C5-selective allylation of siloxyfurans

Nature Synth. 2022, 1, 641-648.

46.

Erin. G. Moloney, Deepak. T. Gangadharan, Vishal Yeddu, Dongyang Zhang, Shahram Moradi, Abdelrahman M. Askar, Michael. M. Adachi, David C. Leitch, and Makhsud I. Saidaminov.*

Inhibition of Amine–Water Proton Exchange Stabilizes Perovskite Ink for Scalable Solar Cell Fabrication

Chem. Mater. 2022, 34, 4394-4402.

45.

David Leitch, Jingjun Huang, Matthew Isaac, Ryan Watt

Palladium complex and catalyst embodiments and methods of making and using the same

World Patent Application WO2022153180A1, Published 2022.

44.

David C. Leitch* and Joseph Becica

High-Throughput Experimentation in Organometallic Chemistry and Catalysis

Comprehensive Organometallic Chemistry IV 2022, 13, 502-555.

43.

Nahiane Pipaon Fernandez, Gregory Gaube, Kyla J. Woelk, Mathias Burns, Damian P. Hruszkewycz, and David C. Leitch*

Palladium-Catalyzed Direct C–H Alkenylation with Enol Pivalates Proceeds via Reversible C–O Oxidative Addition to Pd(0)

ACS Catal. 2022, 12, 6997-7003.

ChemRxiv 2021, DOI: 10.33774/chemrxiv-2021-s62r6.

42.

Kushal Dhake, Kyla J. Woelk, Joseph Becica, Andy Un, Sarah E. Jenny, and David C. Leitch*

Beyond Bioisosteres: Divergent Synthesis of Azabicyclohexanes and Cyclobutenyl Amines from Bicyclobutanes.

Angew. Chem. Int. Ed. 2022, 61, e202204719.

ChemRxiv 2021, DOI: 10.33774/chemrxiv-2021-p0fzf.

41.

Jingru Lu, Sofia Donnecke, Irina Paci,* and David C. Leitch*

A reactivity model for oxidative addition to palladium enables quantitative predictions for catalytic cross-coupling reactions.

Chem. Sci. 2022, 13, 3477-3488.

ChemRxiv 2021, DOI: 10.33774/chemrxiv-2021-qc8vv-v2.

40.

Gregory Gaube, Nahiane Pipaon Fernandez, and David C. Leitch*

An evaluation of palladium-based catalysts for the base-free borylation of alkenyl carboxylates.

New J. Chem. 2021, 45, 20095-20098.

ChemRxiv 2021, DOI: 10.33774/chemrxiv-2021-x0h4m-v2.

39.

Joseph Becica, Owen D. Glaze, Damian P. Hruszkewycz,* Graham E. Dobereiner,* and David C. Leitch*

The influence of additives on orthogonal reaction pathways in the Mizoroki-Heck arylation of vinyl ethers.

React. Chem. Eng. 2021, 6, 1212-1219.

38.

Emma Dennis, Victor Burlakov, Jingjun Huang, Soumya Kundu, Deepak Thrithamarassery Gangadharan, Devon Richtsmeier, Magdalena Bazalova-Carter, David C. Leitch, and Makhsud I. Saidaminov*

High length-to-width aspect ratio lead bromide microwires via perovskite-induced local concentration gradient for X-ray detection.

CrystEngComm 2021, 23, 2215-2221.

37.

Jingjun Huang, Matthew Isaac, Ryan Watt, Joseph Becica, Emma Dennis, Makhsud I. Saidaminov, William A. Sabbers, and David C. Leitch*

(DMP)DAB–Pd–MAH: A Versatile Pd(0) Source for Precatalyst Formation, Reaction Screening, and Preparative-Scale Synthesis.

ACS Catalysis 2021, 11, 5636–5646.

ChemRxiv 2021, DOI: 10.26434/chemrxiv.13604777.v1.

36.

Joseph Becica and David C. Leitch*

C-O Bond Activation as a Strategy in Palladium-Catalyzed Cross-Coupling.

Synlett 2021, 32, 641-646.

Invited Synpact account.

35.

Joseph Becica, Oliver R. J. Heath, Cameron H. M. Zheng, and David C. Leitch*

Palladium-Catalyzed Cross-Coupling of Alkenyl Carboxylates.

Angew. Chem. Int. Ed. 2020, 59, 17277-17281.

34.

Joseph Becica, Gregory Gaube, William A. Sabbers, and David C. Leitch*

Oxidative addition of activated aryl-carboxylates to Pd(0): divergent reactivity dependant on temperature and structure.

Dalton Trans. 2020, 49, 16067-16071.

Part of the special issue New Talent: Americas

33.

John Jin Lim,* Frank Dixon Jr., David C. Leitch, John Kowalski, Mark Nilson, Charles Goss, Roy Flanagan, Sean Hayes, and Michael J. Murphy

Playing with Fire? A Safe and Effective Deactivation of Raney Cobalt using Aqueous Sodium Nitrate.

Org. Process Res. Dev. 2020, 24, 1180-1184.

32.

John Jin Lim,* Kenneth Arrington,* Anna L. Dunn, David C. Leitch, Ian Andrews, Neil R Curtis, Mark J. Hughes, Daniel Tray, Charles E. Wade, Matthew P. Whiting, Charles Goss, Yangmu Chloe Liu, and Brian Roesch

A Flow Process Built Upon a Batch Foundation – Preparation of a Key Amino-Alcohol Intermediate via Multi-Stage Continuous Synthesis.

Org. Process Res. Dev. 2020, 24, 1927-1937.

31.

Joseph Becica, Damian P. Hruszkewycz, Janelle E. Steves, Jennifer M. Elward, David C. Leitch,* and Graham E. Dobereiner*

High-Throughput Discovery and Evaluation of a General Catalytic Method for N-Arylation of Weakly Nucleophilic Sulfonamides.

Org. Lett. 2019, 21, 8981-8986.

(Open-access preprint available on ChemRxiv, DOI:10.26434/chemrxiv.9108461)

30.

Jonathan D. Egbert, Edwin C. Thomsen, Stacy A. O'Neill-Slawecki, Douglas M. Mans, David C. Leitch, Lee J. Edwards, Charles E. Wade, and Robert S. Weber*

Development and Scale-up of Continuous Electrocatalytic Hydrogenation of Functionalized Nitroarenes, Nitriles and Unsaturated Aldehydes.

Org. Process Res. Dev. 2019, 23, 1803-1812.

29.

Gregg A. Barcan, Jose J Conde, Mohamed K. Mokhallalati, Mark G. Nilson, Shiping Xie,* C. Liana Allen, Yemane W. Andemichael, Nicholas A. Calandra, David C. Leitch, Ling Li, and Michael J. Morris

Nucleophilic Aromatic Substitutions of 2-Halo-5- (sulfamoyl)benzoic Acids and N,O-Bis-alkylation via Phase Transfer Catalysis: Synthesis of RoR-gamma Inverse Agonist GSK2981278A.

Org. Process Res. Dev. 2019, 23, 1396-1406.

28.

Steven M. Mennen,* Carolina Alhambra, C. Liana Allen, Mario Barberis, Simon Berritt, Thomas A. Brandt, Andrew D. Campbell, Jesús Castañón, Alan H. Cherney, Melodie Christensen, David B. Damon, J. Eugenio de Diego, Susana García-Cerrada, Pablo García-Losada, Rubén Haro, Jacob Janey, David C. Leitch, Ling Li, Fangfang Liu, Paul C. Lobben, David W. C. MacMillan, Javier Magano, Emma McInturff, Sebastien Monfette, Ronald J. Post, Danielle Schultz, Barbara J. Sitter, Jason M. Stevens, Iulia I. Strambeanu, Jack Twilton, Ke Wang, Matthew A. Zajac

The Evolution of High-Throughput Experimentation in Pharmaceutical Development, and Perspectives on the Future.

Org. Process Res. Dev. 2019, 23, 1213-1242.

Selected as an ACS Editors' Choice Paper (open access).

27.

Kenneth Arrington, Gregg A. Barcan, Nicholas A. Calandra, Greg A. Erickson, Ling Li, Li Liu, Mark G. Nilson, Iulia I. Strambeanu, Kelsey F. VanGelder, John L. Woodard, Shiping Xie, C. Liana Allen, John A. Kowalski,* and David C. Leitch*

Convergent Synthesis of the NS5B Inhibitor GSK8175 Enabled by Transition Metal Catalysis.

J. Org. Chem. 2019, 84, 4680-4694.

Part of the special issue Excellence in Industrial Organic Synthesis 2019.

26.

C. Liana Allen, David C. Leitch, Michael S. Anson, and Matthew A. Zajac*

The power and accessibility of high-throughput methods for catalysis research.

Nature Catalysis 2019, 2, 2-4.

25.

Anna L. Dunn,* David C. Leitch,* Michel Journet, Michael Martin, Elie A. Tabet, Neil R. Curtis, Glynn Williams, Charles Goss, Tony Shaw, Bernie O’Hare, Charles Wade, Matthew A. Toczko, and Peng Liu

Selective Continuous Flow Iodination Guided by Direct Spectroscopic Observation of Equilibrating Aryl Lithium Regioisomers.

Organometallics 2019, 38, 129-137.

Part of the special issue The Roles of Organometallic Chemistry in Pharmaceutical Research and Development.

24.

Justin M. Kaplan, Damian P. Hruszkewycz, Iulia I. Strambeanu, Christopher J. Nunn, Kelsey F. VanGelder, Anna L. Dunn, Derek I. Wozniak, Graham E. Dobereiner, and David C. Leitch*

Scalable and Chemoselective Synthesis of γ-Keto Esters and Acids via Pd-Catalyzed Carbonylation of Cyclic β-Chloro Enones.

Organometallics 2019, 38, 85-96.
Part of the special issue The Roles of Organometallic Chemistry in Pharmaceutical Research and Development.

23.

Julien C. Vantourout, Ling Li, Enrique Bendito-Moll, Bela E. Bode, Mark G. Nilson, John L. Woodard, Albert Isidro-Llobet, Katherine M. P. Wheelhouse, David C. Leitch,* and Allan J. B. Watson*

Mechanistic Insight Enables Practical, Scalable, Room Temperature Chan-Lam N-Arylation of N-Aryl Sulfonamides.

ACS Catalysis 2018, 8, 9560-9566.

22.

John Jin Lim,* and David C. Leitch

Lewis Acid Catalyzed Addition of Benzophenone Imine to Epoxides Enables the Selective Synthesis of Primary Aminoalcohols.

Org. Process Res. Dev. 2018, 22, 641-649.

21.

David C. Leitch, Jay A. Labinger, John E. Bercaw, and Yan C. Lam

Method for the Conversion of Hydrocarbons via Tandem Transfer Hydrogenation and Oligomerization.
US Patent 9,676,680. Granted June 2017.

20.

David C. Leitch,* Matthew P. John, Paul A. Slavin, and Andrew D. Searle

An Evaluation of Multiple Catalytic Systems for the Cyanation of 2,3-Dichlorobenzoyl Chloride: Application to the Synthesis of Lamotrigine.

Org. Process Res. Dev. 2017, 21, 1815-1821.

19.

David C. Leitch,* Thomas F. Greene, Roisin O’Keeffe, Thomas C. Lovelace, Jeremiah D. Powers, and Andrew D. Searle

A Combined High-Throughput Screening and Reaction Profiling Approach toward Development of a Tandem Catalytic Hydrogenation for the Synthesis of Salbutamol.

Org. Process Res. Dev. 2017, 21, 1806-1814.

18.

Huseyin Erguven, David C. Leitch, Evan N. Keyzer, and Bruce A. Arndtsen*

Development and Cycloaddition Reactivity of a New Class of Pyridine-Based Mesoionic 1,3-Dipole.

Angew. Chem. Int. Ed. 2017, 56, 6078-6082.

Part of the special issue 100th Anniversary of the Canadian Society for Chemistry.

17.

David C. Leitch, Laure Kayser, Zhi-Yong Han, Ali R. Siamaki, Evan N. Keyzer, Ashley Gefen, and Bruce A. Arndtsen*

A Palladium Catalyzed Multicomponent Coupling Approach to Conjugated Poly(1,3-Dipoles) and Polyheterocycles.

Nature Commun. 2015, 6, 7411.

16.

Patricia Horrillo-Martinez, David C. Leitch, Scott A. Ryken, Robert K. Thomson, J. David Beard, Brian O. Patrick, and Laurel L. Schafer*

Titanium Amidate Complexes as Active Catalysts for the Synthesis of High Molecular Weight Polyethylene.

Can. J. Chem. 2015, 93, 775-783.

15.

Jay A. Labinger,* David C. Leitch, John E. Bercaw, Mark A. Deimund, and Mark E. Davis

Upgrading Light Hydrocarbons: A Tandem Catalytic System for Alkane/Alkene Coupling.

Top. Catal. 2015, 58, 494-501.

14.

David C. Leitch, Jay A. Labinger,* and John E. Bercaw*

Scope and Mechanism of Homogeneous Ta/Ir Tandem Catalytic Alkane/Alkene Upgrading using Sacrificial Hydrogen Acceptors.

Organometallics 2014, 33, 3353-3365.

13.

Jacky C.-H. Yim, Jason A. Bexrud, Rashidat O. Ayinla, David C. Leitch, and Laurel L. Schafer*

Bis(amidate)bis(amido) Titanium Complex: A Regioselective Intermolecular Alkyne Hydroamination Catalyst.

J. Org. Chem. 2014, 79, 2015-2028.

12.

Renato Skerlj* et al.

Design of Substituted Imidazolidinylpiperidinylbenzoic Acids as Chemokine Receptor 5 Antagonists: Potent Inhibitors of R5 HIV-1 Replication.

J. Med. Chem. 2013, 56, 8049-8065.

11.

David C. Leitch, Yan C. Lam, Jay A. Labinger,* and John E. Bercaw*

Upgrading Light Hydrocarbons via Tandem Catalysis: A Dual Homogeneous Ta/Ir System for Alkane/Alkene Coupling.

J. Am. Chem. Soc. 2013, 135, 10302-10305.

10.

David C. Leitch, Rachel H. Platel, and Laurel L. Schafer* Mechanistic Elucidation of Intramolecular Aminoalkene Hydroamination Catalyzed by a Tethered Bis(ureate) Complex: Evidence for Proton-Assisted C-N Bond Formation at Zirconium.

J. Am. Chem. Soc. 2011, 133, 15453-15463.

Philippa R. Payne, Jason A. Bexrud, David C. Leitch, and Laurel L. Schafer*

Asymmetric Hydroamination Catalyzed by in situ Generated Chiral Amidate and Ureate Complexes of Zirconium - Probing the Role of the Tether in Ligand Design.

Can. J. Chem. 2011, 89, 1222-1229.

David C. Leitch, Courtney S. Turner, and Laurel L. Schafer*

Isolation of Catalytic Hydroamination Intermediates: Insertion of Electron-Rich Alkynes into a Zirconium–Amido Bond.

Angew. Chem. Int. Ed. 2010, 49, 6382-6386.

David C. Leitch and Laurel L. Schafer*

Zirconium Alkyl Complexes Supported by Ureate Ligands: Synthesis, Characterization, and Precursors to Metal−Element Multiple Bonds.

Organometallics 2010, 29, 5162-5172.

Part of the Dietmar Seyferth Festschrift.

David C. Leitch, Philippa R. Payne, Christine R. Dunbar, and Laurel L. Schafer*
Broadening the Scope of Group 4 Hydroamination Catalysis using a Tethered Ureate Ligand.

J. Am. Chem. Soc. 2009, 131, 18246-18247.

Jason A. Bexrud, Patrick Eisenberger, David C. Leitch, Philippa R. Payne, and Laurel L. Schafer*

Selective C–H Activation α to Primary Amines. Bridging Metallaaziridines for Catalytic, Intramolecular α-Alkylation.

J. Am. Chem. Soc. 2009, 131, 2116-2118.

David C. Leitch, J. David Beard, Robert K. Thomson, Vincent A. Wright, Brian O. Patrick, and Laurel L. Schafer*

N,O Chelates of the Group 4 Metals: Contrasting the Use of Amidates and Ureates in the Synthesis of Metal Dichlorides.

Eur. J. Inorg. Chem. 2009, 2691-2701.

Mark C. Wood, David C. Leitch, Charles S. Yeung, Jennifer A. Kozak, and Laurel L. Schafer*

Chiral Neutral Zirconium Amidate Complexes for the Asymmetric Hydroamination of Alkenes.

Angew. Chem. Int. Ed. 2007, 46, 354-358.

Zhe Zhang, David C. Leitch, Man Lu, Brian O. Patrick, and Laurel L. Schafer*
An Easy-To-Use, Regioselective, and Robust Bis(Amidate) Titanium Hydroamination Precatalyst: Mechanistic and Synthetic Investigations Toward the Preparation of Tetrahydro-isoquinolines and Benzoquinolizine Alkaloids.

Chem. Eur. J. 2007, 13, 2012-2022.

Jason A. Bexrud, J. David Beard, David C. Leitch, and Laurel L. Schafer*

Intramolecular Hydroamination of Unactivated Olefins with Ti(NMe2)4 as a Precatalyst.

Org. Lett. 2005, 7, 1959-1962.

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